Dr. Nahlah Elkudssiah Ismail graduated with a Bachelor Degree in Pharmacy (Hons) from Universi.Physiological Biochemistry, Metabolic Correction, Orthomolecular Medicine, Al.The Larix Journals always strives to be a platform for Academicians, new Researchers, Authors, Engineers and Technocrats and Engineering Scholars.Since inception, Larix International Journals is continuously publishing original and best quality research articles.
Increased A content within neuronal cell mitochondria is a pathological feature in both human and mouse models with AD. Koteswara Rao Valasani Free Radical ProductionThis accumulation of A within the mitochondrial landscape perpetuates increased free radical production and activation of the apoptotic pathway. Human Presequence Protease (hPreP) is responsible for the degradation of mitochondrial amyloid- peptide in human neuronal cells, and is thus an attractive target to increase the proteolysis of A. Therefore, it offers a potential target for Alzheimers drug design, by identifying potential activators of hPreP. We applied structure-based drug design, combined with experimental methodologies to investigate the ability of various compounds to enhance hPreP proteolytic activity. Compounds 3c 4c enhanced hPreP-mediated proteolysis of A (142), pF1 (254) and fluorogenic-substrate V. These results suggest that activation of hPreP by small benzimidazole derivatives provide a promising avenue for AD treatment. Campus Road, Room 153A, Lawrence, KS, 66045, (785)864-6414, 711 TTY.
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